What is Platelet-Rich Plasma (PRP)?

PRP is a concentrated solution derived from a patient's own blood, containing platelets with growth factors that promote healing. The procedure involves blood collection, centrifugation to separate components, and targeted injection of the platelet-rich solution. PRP is  increasingly used for skin rejuvenation and treatment of hair loss.

 Typically requires multiple sessions (3-4 initial treatments, 4-6 weeks apart) with maintenance treatments every 4-6 months.

The procedure usually takes about 60-90 minutes in total. Results vary between individuals, and multiple treatments are usually needed to see noticeable improvement.

Mechanism of Action

PRP contains concentrated growth factors which act on hair follicles by:

- Stimulating anagen (growth) phase prolongation

- Activating dormant hair follicles

- Promoting neovascularisation around follicular units

- Decreasing local inflammation

Clinical Evidence

Recent systematic reviews and meta-analyses indicate that PRP demonstrates efficacy for androgenetic alopecia with:

- Significant improvements in hair density compared to placebo

- Modest effects on hair thickness in some studies

- Better outcomes when used in early to moderate stages of hair loss

- Variable results depending on preparation protocols

Treatment Schedule

- 3-4 initial sessions at 4-6 week intervals

- Maintenance treatments every 4-12 months

Limitations

- Variable platelet concentrations between systems

- Limited long-term efficacy data beyond 12 months

- Better results typically seen in combination therapy and use of hair products

What Are Exosomes?

Exosomes are nano-sized extracellular vesicles (30-150nm) that function as cellular messengers, transferring proteins, lipids, and genetic material between cells. In hair restoration, they are primarily derived from:

- Mesenchymal stem cells (MSCs)

- Adipose-derived stem cells (ADSCs)

- Dermal papilla cells (DPCs)

Mechanism of Action

Exosomes promote hair growth through multiple pathways:

- Delivering growth factors and signalling proteins to hair follicles

- Promoting angiogenesis around follicular units

- Modulating inflammatory responses

- Activating dermal papilla cells

- Extending the anagen (growth) phase of the hair cycle

Clinical Evidence*

Recent systematic reviews indicate:

- Significant increases in hair density (9.5-35 hairs/cm²) and thickness

- Effective across different alopecia types

- Minimal adverse events reported

- Potential synergistic effects when combined with microneedling

Treatment Considerations

- Usually administered via topical application following microneedling

- Multiple sessions typically recommended (3-6 treatments)

- Results develop progressively over 2-6 months

- Considered complementary to other hair restoration approaches

NOTE: Exosomes represent an emerging treatment option that may offer advantages through their cell-free approach, though long-term clinical data continues to evolve.

Combination of PRP therapy with  microneedling enhances delivery of growth factors. Treatment schedule typically includes 3-4 initial sessions at 4-6 week intervals.